About fIVE DB Open

fIVE DB (from In Vitro Experiments DataBase) is an InSysBio UK Ltd project for collecting and processing information from in vitro experiments.

fIVE DB contains quantitative data obtained in vitro and ex vivo for human cells or cell lines. The data describe major cell processes such as proliferation, cell death, differentiation, activation, secretion, and others. The data are collected from the public domain sources, processed, and stored in fIVE DB as content.

Data processing includes the calculation of parameters suitable for describing cell processes with mathematical models. Parameter calculation is based on the InSysBio approach to implementing regulator effects in the models (more details here) and pre-derived equations describing typical in vitro experiments (please find more information here).

Key features of fIVE DB:

Search by cell or by process type
The query may include Regulator (activator or inhibitor) or Modifier of the process rate, parameter name (using the terms proposed by InSysBio for describing regulator effects), tissue type, and patient group type (healthy control or disease type)
Table representation of the search results with possibility of export to the CSV format

Content of fIVE DB:

206 process regulator molecules, click to view details;
- 12-Hydroxyeicosatetraenoic acid
- 15(R)-Hydroxyeicosatetraenoic acid
- 5-oxo-ETE
- Acetate
- Adiponectin
- Albumin
- Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
- Amphiregulin
- aMSH
- Amyloid beta (1-40)
- Amyloid beta (1-42)
- Amyloid beta (25-35)
- Angiotensin II
- antibacterial protein LL-37
- anti-CD28
- anti-CD3
- Ascorbic acid
- As-MIF
- Beta-defensin 103
- Butyrate
- C1q-related factor
- C3 binding glycoprotein
- C3a
- C5a (сomplement component)
- C5a anaphylatoxin chemotactic receptor 1
- Calcitriol
- Capsid protein
- C-C motif chemokine 19
- C-C motif chemokine 2
- C-C motif chemokine 20
- C-C motif chemokine 21
- C-C motif chemokine 25
- C-C motif chemokine 3
- C-C motif chemokine 4
- C-C motif chemokine 5
- C-C motif chemokine 7
- CD40L
- Chymase
- Collagen alpha-1(IV) chain
- Concanavalin A
- CoQ10
- C-X-C motif chemokine 10
- C-X-C motif chemokine 13
- C-X-C motif chemokine 3
- C-X-C motif chemokine 9
- CXCL16
- CXCL2
- CXCL4
- Cycloheximide
- Defensin beta 4A
- Dermcidin-1L (DCD-1L)
- Eluted antigen of P. acnes
- Endothelin-1
- Enterotoxin type B
- Eotaxin
- Erythropoietin
- Estradiol
- Ethanol
- Fibroblast growth factor 2
- Fibroblast growth factor 7
- Fibronectin
- Flagellin
- Fractalkine
- FSTL1
- GH (growth hormone/somatotropin)
- Glucose
- Glutamine
- gp120
- gp160 (HIV-1)
- Granulocyte colony-stimulating factor
- Granulocyte-macrophage colony-stimulating factor
- Growth-regulated alpha protein
- hBD-1 (human β-defensin 1)
- hBD-4 (human β-defensin 4)
- Hepatocyte growth factor
- High mobility group box 1 (HMGB1, amphoterin)
- Histamine
- Hsp70
- Hydrogen Peroxide
- iE-DAP
- IFNa
- IgA
- IgE
- IGF1
- IGFBP-3
- IGFBP-5
- IgG
- IgG2
- IL1
- IL12
- IL18BP (Interleukin-18 Binding Protein)
- IL23 (p19/p40)
- IL27
- Inhibin beta A chain
- Insulin
- Insulin-like growth factor II
- Interferon alpha-2
- Interferon beta
- Interferon gamma
- Interferon lambda-1
- Interleukin-1 alpha
- Interleukin-1 beta
- Interleukin-1 receptor antagonist protein
- Interleukin-10
- Interleukin-13
- Interleukin-15
- Interleukin-17A
- Interleukin-17F
- Interleukin-18
- Interleukin-19
- Interleukin-2
- Interleukin-21
- Interleukin-22
- Interleukin-24
- Interleukin-25
- Interleukin-26
- Interleukin-3
- Interleukin-31
- Interleukin-33
- Interleukin-34
- Interleukin-36 alpha
- Interleukin-36 gamma
- Interleukin-37
- Interleukin-4
- Interleukin-5
- Interleukin-6
- Interleukin-7
- Interleukin-8
- Interleukin-9
- Isoform 1 of Interleukin-32
- Isoform 2 of Interleukin-6 receptor subunit alpha
- Kit ligand
- Laminin subunit alpha-1
- Leptin
- Leukotriene B4
- LIF
- Lipopolysaccharide-binding protein
- lipoxin A4
- LPS
- Lymphotoxin-alpha
- Lysophosphatidylcholine
- Macrophage colony-stimulating factor 1
- Macrophage migration inhibitory factor
- Mannoprotein antigen from C. albicans
- Mannose-binding protein C
- Melanoma-associated antigen 1
- Monosodium urate crystals
- MSPa (macrophage stimulating protein a)
- Muramyl Dipeptide
- Myelin basic protein
- Myelin-oligodendrocyte glycoprotein
- N-Formyl-Met-Leu-Phe
- Nicotinamide phosphoribosyltransferase
- Nicotinamide riboside
- Oncostatin-M
- P0
- P2b
- Palmitic Acid
- PD1L1
- PDGF
- PDGF-AB
- Peptidase 1
- PGE2
- PHA
- Platelet-Activating Factor (PAF)
- Platelet-derived growth factor subunit B
- PMA
- Poly I:C
- Potassium
- Pro-epidermal growth factor
- Progesterone
- Progesterone-induced-blocking factor 1
- Pro-interleukin-16
- Prolactin
- Propionate
- Protransforming growth factor alpha
- PSG
- Psoriasin
- SAP
- sCD13
- sCD40L
- Serotonin
- sIgA
- Silicon Dioxide
- Sm29
- Sodium Chloride
- Sodium hydrosulfide (NaHS)
- Spike glycoprotein
- Spike protein S1
- Stromal cell-derived factor 1
- Superoxide dismutase [Cu-Zn]
- Tax-1
- Testosterone
- Tetanus toxin
- Thrombin
- Thrombopoietin
- Thymic stromal lymphopoietin
- Toxic shock syndrome toxin-1
- Transforming growth factor beta-1 proprotein
- Tretinoin
- Tumor necrosis factor
- Tumor necrosis factor ligand superfamily member 12
- Tumor necrosis factor ligand superfamily member 13
- Tumor necrosis factor ligand superfamily member 13B
- VIP peptides
- ZnSO4
159 secretory product molecules, click to view details;
- 6-Keto-prostaglandin F1alpha
- 72 kDa type IV collagenase
- Basigin
- Beta-2-microglobulin
- Beta-nerve growth factor
- Bone morphogenetic protein 2
- C5a (сomplement component)
- C-C motif chemokine 1
- C-C motif chemokine 13
- C-C motif chemokine 17
- C-C motif chemokine 18
- C-C motif chemokine 2
- C-C motif chemokine 20
- C-C motif chemokine 22
- C-C motif chemokine 23
- C-C motif chemokine 24
- C-C motif chemokine 26
- C-C motif chemokine 3
- C-C motif chemokine 4
- C-C motif chemokine 5
- C-C motif chemokine 7
- C-C motif chemokine 8
- CCL28
- Ceruloplasmin
- Complement Bb
- Complement C3
- C-X-C motif chemokine 10
- C-X-C motif chemokine 11
- C-X-C motif chemokine 13
- C-X-C motif chemokine 3
- C-X-C motif chemokine 5
- C-X-C motif chemokine 6
- C-X-C motif chemokine 9
- CXCL16
- CXCL2
- CXCL4
- Defensin beta 4A
- DKK1
- Eosinophil cationic protein
- Eotaxin
- Fas
- FasL
- Fibroblast growth factor 2
- Fibronectin
- Fms-related tyrosine kinase 3 ligand
- Fractalkine
- Granulocyte colony-stimulating factor
- Granulocyte-macrophage colony-stimulating factor
- Growth-regulated alpha protein
- Hepatocyte growth factor
- HIF1a
- High mobility group box 1 (HMGB1, amphoterin)
- HNPs (defensins)
- Hsp70
- Hyaluronic acid (HA)
- Hydrogen Peroxide
- IFNa
- IgA
- IgE
- IGF1
- IgG
- IgM
- IL1
- IL12
- IL17A/F
- IL18BPa
- IL-1F10
- IL23 (p19/p40)
- IL27
- IL2R
- Inhibin beta A chain
- Inhibin beta B chain
- Intercellular adhesion molecule 1
- Interferon alpha-2
- Interferon beta
- Interferon gamma
- Interferon lambda-1
- Interleukin-1 alpha
- Interleukin-1 beta
- Interleukin-1 receptor antagonist protein
- Interleukin-10
- Interleukin-11
- Interleukin-12 subunit beta
- Interleukin-13
- Interleukin-15
- Interleukin-17A
- Interleukin-17F
- Interleukin-18
- Interleukin-2
- Interleukin-2 receptor subunit alpha
- Interleukin-20
- Interleukin-21
- Interleukin-22
- Interleukin-23 subunit alpha
- Interleukin-25
- Interleukin-3
- Interleukin-31
- Interleukin-32
- Interleukin-33
- Interleukin-4
- Interleukin-5
- Interleukin-6
- Interleukin-7
- Interleukin-8
- Interleukin-9
- Interstitial collagenase
- Isoform 2 of Interleukin-6 receptor subunit alpha
- Kit ligand
- Leukotriene B4
- leukotriene C4
- LIF
- Lymphotoxin-alpha
- Macrophage colony-stimulating factor 1
- Macrophage migration inhibitory factor
- Matrix metalloproteinase-9
- MCAF
- Metalloproteinase inhibitor 1
- Metalloproteinase inhibitor 2
- MMP-13
- MMP3
- Monocyte differentiation antigen CD14
- Neopterin
- Neutrophil gelatinase-associated lipocalin
- Nitric oxide
- Nitrite
- Oncostatin-M
- Osteopontin (OPN)
- PDGF
- PDGF-AB
- PGD2
- PGE2
- Plasminogen activator inhibitor 1
- Platelet-derived growth factor subunit A
- Platelet-derived growth factor subunit B
- Pro-epidermal growth factor
- Pro-interleukin-16
- Protein Wnt-5a
- Protransforming growth factor alpha
- RANKL
- Resistin
- sC5b-9
- sCD30
- sCD40L
- Sgp130 (Soluble Glycoprotein 130)
- sIL-1Ra
- Stromal cell-derived factor 1
- Stromelysin-2
- Superoxide
- Thrombopoietin
- Thymic stromal lymphopoietin
- Transforming growth factor beta-1 proprotein
- Transforming growth factor beta-2 proprotein
- Tumor necrosis factor
- Tumor necrosis factor ligand superfamily member 13B
- Tumor necrosis factor receptor superfamily member 1A
- Tumor necrosis factor receptor superfamily member 1B
- Vascular cell adhesion protein 1
- Vascular endothelial growth factor A, long form
- VIP peptides
149 cell types, click to view details;
- activated aNAV B cells
- Activated B cells
- activated Blood-derived mast cells
- activated BMSC
- activated CD4+ T-cells
- Activated CD8+ T cells
- Activated dental pulp cells
- activated epithelial cells
- activated fibroblast-like synoviocytes
- activated fibroblasts
- Activated iNKT cells
- activated keratinocytes
- Activated lymphocytes
- activated macrophages
- activated mast cells
- Activated memory B cells
- activated memory CD4 T cells
- Activated memory Th1
- Activated memory Th17
- Activated memory Th2
- Activated monocyte-derived dendritic cells
- Activated monocytes
- activated mononuclear cells
- activated PBMC
- activated pDC
- activated PMN
- Activated T-cells
- activated T-cells (CD4+CD25-)
- activated T-cells (CD4+CD25+)
- Activated Th1
- Activated Th17
- Activated Th2
- activated Th-cells
- Adipocytes
- Adrenocortical cells
- AG-EB+ erythroid nuclear cells
- Airway smooth muscle cell
- Amniotic epithelial cells (AECs)
- aNAV B cells
- Arterial endothelial cells
- Astrocytes
- B cells
- BAL cells
- Basophil progenitor cells
- Basophils
- Biliary epithelial cells
- Blood-derived mast cells
- BMSC
- CBMC
- CD16- monocytes
- CD16+ monocytes
- CD4+HLA-DR-
- CD4+HLA-DR+
- CD45RO memory T-helper
- CD56bright NK cells
- Chondrocytes
- Cytokine-induced killer cells
- Cytotrophoblast cells
- Decidual stromal cell
- Dendritic Cells (DC)
- Dental Pulp Cells
- Dermal fibroblasts (DFs)
- Endometrial stromal cells (ESCs)
- Endothelial Cells
- Eosinophil
- Epithelial cells
- Fibroblast-like synoviocytes
- Fibroblasts
- Gl A+ erythroid nuclear cells
- Glial cells
- Granulocytes
- Hepatocytes
- Immature DCs (iDCs)
- iNKT
- iTreg
- Kc
- Keratinocytes
- Leukemic blasts
- Lymphoblasts
- Lymphocytes
- Macrophages
- Malignant plasma B cells
- Mast cells
- Mature Dendritic Cells (DC)
- Megakaryoblast
- Megakaryocytes
- Melanocytes
- Memory mononuclear cell
- Merkel cells
- Mesenchymal progenitor cell
- Microglial cells
- Microvascular endothelial cells
- Monocyte-derived dendritic cells
- Monocyte-derived iDC
- Monocyte-derived macrophages
- Monocytes
- Monocytes/macrophages
- Mononuclear cells
- MPC
- Myeloid angiogenic cells
- Myeloid DC2
- Myeloid Dendritic Cells (mDC)
- Myoblasts
- Naive B cells
- Naïve CD4 T cells
- Naive mononuclear cell
- Naive T-cells
- Natural killer T-cells
- Neural crest stem-like cells (NCSCs)
- Neutrophil
- NK/NK-like cells
- NK-cells
- NK-cells (CD56+)
- Nucleus pulposus cells
- orbital fibroblasts
- Osteoblasts (OB)
- Osteogenic-differentiated MPC (dOB)
- PBMC
- Periodontal ligament cells
- Pigment epithelium
- Plasma B cells
- Plasmacytoid Dendritic Cells (pDC)
- Podocytes
- Pre-adipocytes
- precursor B cells
- Progenitor cells CD34+
- Retroorbital fibroblasts
- Smooth muscle cells
- Sputum cells
- Stem cells
- Stromal cells
- Stromovascular cells
- Synoviocytes
- Tc1-cell
- Tc-cells
- T-cells
- Th1
- Th17-cells
- Th1-cells
- Th22-cells
- Th2-cells
- Th9-cells
- Th-cells
- T-helper lymphocytes
- Thyrocytes
- TIMC
- Treg-cells
- Trophoblasts
- Whole blood cells
130 parameters for Migration.
194 parameters for Cell Death.
49 parameters for Proliferation.
15564 parameters for Secretion.
10 parameters for Differentiation.
data extracted from 843 papers/other public sources.

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e-mail for correspondence: support@insysbio.com

About fIVE DB Open

206 process regulator molecules, click to view details;

159 secretory product molecules, click to view details;

149 cell types, click to view details;