About fIVE DB Open

fIVE DB (from In Vitro Experiments DataBase) is an InSysBio project for in vitro experiments information collection and processing.

fIVE DB contains the quantitative data obtained in vitro and ex vivo for human cells or cell lines. The data describes major cell processes such as proliferation, cell death, differentiation, activation, secretion, and others. Data is collected from the public domain sources, processed, and stored in the fIVE DB as content.

Data processing includes the calculation of parameters suitable for cell process description with mathematical models. Parameters calculation is based on the InSysBio way of regulators impact implementation in the models (more details here) and pre-derived equations describing typical in vitro experiments (please find more information here).

Key features of fIVE DB:

• Search by cell or by process type
• The query may include Regulator (activator or inhibitor) or Modifier of the process rate, parameter name (in the terms proposed by InSysBio for regulators effect description), tissue type, and patient group type (healthy control or disease type)
• Table representation of the search results with possibility of export to the CSV format

Content of fIVE DB:

• 126 process regulators molecules, press to view details;

  • 12-hydroxyeicosatetraenoic acid (12-HETE)
  • 5-oxo-ETE
  • Acetate
  • Activin A
  • Adiponectin
  • aMSH
  • Amyloid beta (1-40)
  • Amyloid beta (25-35)
  • Angiotensin II
  • anti-CD28
  • anti-CD3
  • Anti-IgE
  • Ascorbic acid
  • Butyrate
  • C3 binding glycoprotein
  • C5a receptor (CD88)
  • Calcitriol 1,25-(OH)-D3
  • Cathelicidin (LL-37)
  • CCL11
  • CCL20
  • CCL21
  • CCL25
  • CD40L
  • ConA
  • CoQ10
  • CpG
  • CXCL1
  • CXCL10
  • CXCL12
  • CXCL13
  • CXCL16
  • CXCL2
  • CXCL3
  • CXCL4
  • CXCL9
  • Cycloheximide
  • Dermcidin-1L (DCD-1L)
  • Eluted antigen of P. acnes
  • Endothelin-1
  • Epidermal Growth Factor (EGF)
  • Erythropoietin(EPO)
  • Estradiol
  • Folic acid
  • Forskolin
  • GD1a
  • GD1b
  • GD2
  • GH (growth hormone/somatotropin)
  • Glutamine
  • GM1
  • GM2
  • GM-CSF
  • gp120
  • GQ1b
  • GT1b
  • hBD-1 (human β-defensin 1)
  • hBD-2 (human β-defensin 2)
  • hBD-3 (human β-defensin 3)
  • hBD-4 (human β-defensin 4)
  • Hepatocyte growth factor (HGF)
  • Histamine
  • HNP-1 (a-defensin-1)
  • IFNa [Interferon Alpha]
  • IFNb
  • IFNg
  • IgA
  • IgE
  • IGF1
  • IGF2
  • IGFBP-3
  • IGFBP-5
  • IgG
  • IL1
  • IL10
  • IL12
  • IL13
  • IL15
  • IL16
  • IL17
  • IL17a
  • IL17F
  • IL18
  • IL18BP (Interleukin-18 Binding Protein)
  • IL1a
  • IL1b
  • IL1RA
  • IL2
  • IL22
  • IL25
  • IL29
  • IL3
  • IL33
  • IL34
  • IL37
  • IL4
  • IL5
  • IL6
  • IL7
  • IL8
  • IL9
  • Leptin
  • LIF
  • LPS
  • MBL (Mannose-binding lectin)
  • MIF
  • MMP1
  • MSPa (macrophage stimulating protein a)
  • Palmitate
  • PDGF-BB [Platelet Derived Growth Factor-BB]
  • PHA
  • PMA
  • Potassium
  • Progesterone
  • Propionate
  • PSG
  • Psoriasin
  • Retinoic acid
  • SCF
  • Scrambled cathelicidin (sLL-37)
  • sIgA
  • Spike protein S1
  • Tax-1
  • TGFa
  • TGFb
  • TGFb1
  • TNFa

• 92 secretory products molecules, press to view details;

  • Beta-2-microglobulin
  • b-FGF (basic fibroblast growth factor, FGF2)
  • C3 (Complement component 3)
  • CCL11
  • CCL13
  • CCL17
  • CCL18
  • CCL2
  • CCL20
  • CCL22
  • CCL24
  • CCL3
  • CCL4
  • CCL5
  • CCL7
  • CXCL1
  • CXCL10
  • CXCL12
  • CXCL16
  • CXCL5
  • CXCL9
  • EDN
  • Fas
  • FasL
  • GCSF
  • GM-CSF
  • HIF1a
  • HNPs (defensins)
  • ICAM
  • IFNa [Interferon Alpha]
  • IFNg
  • IgA
  • IGF1
  • IgG
  • IgM
  • IL1
  • IL10
  • IL12
  • IL12b (IL23p40)
  • IL12p70
  • IL13
  • IL15
  • IL16
  • IL17
  • IL17a
  • IL17F
  • IL18
  • IL18 BPa
  • IL1a
  • IL1b
  • IL1RA
  • IL2
  • IL21
  • IL22
  • IL23 (p19/p40)
  • IL25
  • IL27
  • IL3
  • IL31
  • IL33
  • IL4
  • IL5
  • IL6
  • IL7
  • IL8
  • IL9
  • LIF
  • LTB4
  • LTC4
  • MCAF
  • MCSF
  • MMP1
  • MMP13
  • MMP3
  • Neopterin
  • NGF [Nerve Growth Factor]
  • NO
  • Osteoprotegerin
  • PDGF
  • PDGF-BB [Platelet Derived Growth Factor-BB]
  • PGE2 [Prostaglandin E2]
  • RANKL
  • sCD30
  • SCF
  • sTNF-R1
  • sTNF-R2
  • Superoxide anion
  • TGFb
  • TGFb1
  • TNFa
  • TNFb
  • VEGF

• 93 cell types, press to view details;

  • activated BMEC
  • Activated CD8+ T cells
  • activated HUVEC
  • Activated lymphocytes
  • activated mast cells
  • Activated monocytes
  • activated mononuclear cells
  • activated PBMC
  • Activated T-cells
  • activated Th-cells
  • Adrenocortical cells
  • AG-EB+ erythroid nuclear cells
  • Airway smooth muscle cell
  • Arterial endothelial cells
  • Astrocytes
  • Basophils
  • B-cells
  • Biliary epithelial cells
  • CD16- monocytes
  • CD16+ monocytes
  • CD4+HLA-DR-
  • CD4+HLA-DR+
  • CD45RA naive T-helper
  • CD45RO memory T-helper
  • CD56bright NK cells
  • CD8+ T-lymphocytes
  • Central memory T-cells
  • Chondrocytes
  • Cytotrophoblast cells
  • Decidual stromal cell
  • Dendritic Cells (DC)
  • Effector memory T-cells
  • Endometrial stromal cells (ESCs)
  • Eosinophil
  • Epithelial cells
  • Fibroblast
  • Fibroblast-like synoviocytes
  • Gl A+ erythroid nuclear cells
  • Glial cells
  • iMDDCs
  • Immature DCs (iDCs)
  • Immature megakaryocytes
  • iTreg
  • Kc
  • Keratinocytes
  • Lymphocytes
  • Macrophages
  • Mast cells
  • Mature Dendritic Cells (DC)
  • Mature megakaryocytes
  • MDMs
  • Megakaryocytes
  • Memory mononuclear cell
  • Merkel cells
  • Microglial cells
  • Monocytes
  • Monocytes/macrophages
  • Mononuclear cells
  • MPC
  • Naïve CD4
  • Naive mononuclear cell
  • Naive T-cells
  • Neural crest stem-like cells (NCSCs)
  • Neutrophil
  • NK-cells
  • NK-cells (CD56+)
  • Osteoblasts (OB)
  • Osteogenic-differentiated MPC (dOB)
  • PBMC
  • Periodontal ligament cells
  • Pigment epithelium
  • Plasma B-cells
  • Stromal cells
  • Synoviocytes
  • Tc1-cell
  • Tc-cells
  • T-cells
  • Tcm(CCR4- CCR7+ CD45RA-)
  • Tcm(CCR4+ CCR7+ CD45RA-)
  • Terminally differentiated effector T cells (EMRA)
  • Th0-cells
  • Th1
  • Th17-cells
  • Th1-cells
  • Th22-cells
  • Th2-cells
  • Th9-cells
  • Th-cells
  • T-helper lymphocytes
  • Thyrocytes
  • TIMC
  • Trophoblasts
  • Whole blood cells
• 85 parameters for Migration.
• 55 parameters for Viability.
• 96 parameters for Proliferation.
• 4222 parameters for Secretion.
• 10 parameters for Differentiation.
• data extracted from 252 papers/other public sources.

Access to fIVE DB Open

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Login: user1

Password: 12345678

e-mail for correspondence: support@insysbio.com